The glypican family of cell surface heparan sulfate proteoglycans is expressed in a tissue specific and developmentally regulated manner. The glypican 4 expression is seen in the mouse brain at embryonic day 10 and later stages and low during early tubule formation but is up-regulated in mature tubules. Hence it is not detected in the midline of the embryo at the stage of intiation of neural tube closure， signifying that glypican-4 is unlikely to play a critical role in convergent extension in the mouse.
应用类型
ELISA， Western blot and Immunofluorescence
免疫原
Anti-human GPC4 mAb， is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with recombinant human GPC4 amino acids 401-529 purified from E. coli.
