Potassium channel toxin alpha-KTx 6.3 (HsTx1) is a 34 amino acid peptidyl toxin isolated from the Heterometrus spinifer (Asia giant forest scorpion, Malaysian black scorpion) venom. HsTx1 is one of the most active peptidic inhibitors of rat KV1.3 channels ever described, with an IC50 of approx. 12 pM4. HsTX1 belongs to a structural class of scorpion K+ channel inhibitors which includes Pandinus imperator toxin 1 (Pi1) and Maurotoxin (MTX), two toxins containing 35 residues and four disulphide bridges.
产品描述
A Potent Blocker of KV1.3 K+ Channels
产品形式
Many K+ channel blockers have been identified in the scorpion venom. These peptide toxins consist of 29 to 39 amino acids, and commonly share three disulfide bonds. Their 3D structure comprises a helix and a double- or triple stranded β-sheet. The functional sites of the toxins are located either on the solvent exposed face of the β-sheet, or on the helix, depending on the targeted type of K+ channel .
