中文名称

广西毒素-1E（50 ug）

英文名字

Guangxitoxin-1E

供应商

Alomone

产品货号

ALO-STG-200-50

产品报价

￥已停产

产品说明书

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购买方式

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产品新闻

背景资料

Guangxitoxin-1E is a 36 amino acid peptidyl toxin isolated from the Chilobrachys jingzhao (Chinese earth tiger) tarantula venom and belongs to the huwentoxin-1 family. Guangxitoxin-1E is a gating modifier of Kv2.1 (KCNB1, IC50 of 1 nM), Kv2.2 (KCNB2, IC50 of 3 nM) and Kv4.3 (KCND3, IC50 of 50 nM) channels. In pancreatic b cells, it enhances glucose-stimulated insulin secretion by broadening the cell action potential and enhancing calcium oscillations. The physiological modulation of Kv2.1 channels during glucose-induced insulin secretion is MgATP-mediated3,4. No significant effect was found on Kv1.2 (KCNA2), Kv1.3 (KCNA3), Kv1.5 (KCNA5), Kv3.2 (KCNC2), Cav1.2 (CACNA1C), Cav2.2 (CACNA1B), Nav1.5 (SCN5A), Nav1.7 (SCN9A) or Nav1.8 (SCN10A) channels.

产品描述

A Potent Gating Modifier of KV2.1, KV2.2 and KV4.3 K+ Channels

产品形式

Guangxitoxin-1E is a 36 amino acid peptidyl toxin isolated from the Chilobrachys jingzhao (Chinese earth tiger) tarantula venom and belongs to the huwentoxin-1 family. Guangxitoxin-1E is a gating modifier of Kv2.1 (KCNB1, IC50 of 1 nM), Kv2.2 (KCNB2, IC50 of 3 nM) and Kv4.3 (KCND3, IC50 of 50 nM) channels. In pancreatic b cells, it enhances glucose-stimulated insulin secretion by broadening the cell action potential and enhancing calcium oscillations. The physiological modulation of Kv2.1 channels during glucose-induced insulin secretion is MgATP-mediated3,4. No significant effect was found on Kv1.2 (KCNA2), Kv1.3 (KCNA3), Kv1.5 (KCNA5), Kv3.2 (KCNC2), Cav1.2 (CACNA1C), Cav2.2 (CACNA1B), Nav1.5 (SCN5A), Nav1.7 (SCN9A) or Nav1.8 (SCN10A) channels.

保存建议

艾美捷为您提供的Alonmone Labs原装进口的Guangxitoxin-1E (50 µg)产品可室温运输，建议您在收到产品后将其置于合适的温度下保存。

其他

Alomone成立于1989年,已经成为全世界科学家信赖的最全面的离子通道研究工具供应商。产品覆盖离子通道、G蛋白耦联受体和神经信号研究所需的一抗、小分子、蛋白质和多肽等。所有Alomone产品均进行了生物实验验证，以冻干粉形式提供，可确保产品生物活性和保质期。Alomone可提供多种包装规格，灵活方便。作为Alomone Labs在中国的区域总代理，艾美捷科技有限公司将为中国客户提供最全面的Alomone Labs产品以及客户订制化服务。

注意

该页面的中文产品信息的翻译，仅供参考。准确的产品信息请以厂家的英文说明书为准。下单前，请浏览说明书确认。

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