µ-Conotoxin SxIIIA is a three-disulfide bridged peptide Conotoxin originally isolated from the venom of the Conus striolatus cone snail. SxIIIA is a blocker of the voltage-gated NaV1.4 channel and has an effective concentration of 50-100 nM and an IC50 of 7 nM for the channel. µ-Conotoxin SxIIIA and other toxins derived from venomous animals such as spiders, scorpions, mollusks or plants exhibit promising therapeutic and specifically analgesic properties.
