SR 33805, a fantofarone derivative, is a potent Ca2+ channel antagonist. It binds allosterically to the a1-subunit of L-type Ca2+ channels (Kd = 20 pM), at a site distinct from other types of blockers. It potently inhibits the Ca2+ channel, and hence prevents Ca2+ influx, in primary mouse cardiac myocytes cultures with IC50 values ranging from 4.1 to 33 nM.
产品描述
A Specific Blocker of L-type Cav Channels
产品形式
Two types of voltage-gated Ca2+ channels (VGCC, CaV) are found in most nonexcitable cells, T-type and the L-type Ca2+ channels.
