Ergtoxin-1 was originally isolated from Centruroides noxius scorpion venom. nErgtoxin-1 blocks specifically Kv11.1 (ERG) K+ channels in different tissues and across species. Patch clamp recordings from cultured cell lines and cardiac myocytes showed specific block of ERG currents with IC50 of 16 nM, and increase firing-rate in neurons as well as cardiac action potential broadening.
产品描述
A Novel Blocker of ERG1 (KV11.1) K+ Channel
产品形式
Ergtoxin-1 was originally isolated from Centruroides noxius scorpion venom. nErgtoxin-1 blocks specifically Kv11.1 (ERG) K+ channels in different tissues and across species. Patch clamp recordings from cultured cell lines and cardiac myocytes showed specific block of ERG currents with IC50 of 16 nM, and increase firing-rate in neurons as well as cardiac action potential broadening.