中文名称

雷诺嗪（100毫克）

英文名字

Ranolazine

供应商

Alomone

产品货号

ALO-R-110-100

产品报价

￥已停产

产品说明书

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购买方式

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产品新闻

背景资料

Ranolazine is an antianginal and anti-ischemic drug that is used in patients with chronic angina. Ranolazine displays a broad pharmacological profile on a number of targets and has complex electrophysiological effects in myocardium. This drug seems to preferentially reduce the persistent late cardiac NaV1.5 Na+ currents with a 50% inhibitory concentration (IC50) of 15 μM, whereas normal transient Na+ currents are less affected, with an IC50 of 135 μM4. The binding site of ranolazine in human cardiac Na+ channels is probably the same as the local anesthetic (LA) receptor within the inner cavity of the Na+ channel, because a single mutation in this channel (e.g., residue hNav1.5-F1760A) alters the ranolazine binding affinity drastically.

产品描述

A Blocker of Voltage-Gated Na+ Channels

产品形式

Voltage-gated Na+ (NaV) channels are essential for the generation and propagation of action potentials in excitable membranes. The NaV channel protein contains four homologous domains (D1-D4), each with six transmembrane segments (S1-S6). There are 9 isoforms (NaV1.1-1.9) found among mammalian excitable tissues, including central nervous system, peripheral nervous system, skeletal muscle, and heart.

保存建议

艾美捷为您提供的Alonmone Labs原装进口的Ranolazine (100 mg)产品可室温运输，建议您在收到产品后将其置于合适的温度下保存。

其他

Alomone成立于1989年,已经成为全世界科学家信赖的最全面的离子通道研究工具供应商。产品覆盖离子通道、G蛋白耦联受体和神经信号研究所需的一抗、小分子、蛋白质和多肽等。所有Alomone产品均进行了生物实验验证，以冻干粉形式提供，可确保产品生物活性和保质期。Alomone可提供多种包装规格，灵活方便。作为Alomone Labs在中国的区域总代理，艾美捷科技有限公司将为中国客户提供最全面的Alomone Labs产品以及客户订制化服务。

注意

该页面的中文产品信息的翻译，仅供参考。准确的产品信息请以厂家的英文说明书为准。下单前，请浏览说明书确认。

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