3R12Rα-Pompilidotoxin (3R12Rα-PMTX) is a mutated form of the α-PMTX, originaly isolated from the solitary wasp (Anoplius samariensis) venom and is a synthetic version of the peptide.
产品描述
An Activator of NaV Channels
产品形式
Pompilidotoxins (PMTX, α and β) are small peptides consisting of 13 amino acids.n α-PMTX induces a unique pattern of repetitive action potentials previous seen with other neurotoxins and thus facilitate both excitatory and inhibitory synaptic transmission.nRecently it was found that this toxin slows the Na+-channel inactivation, without changing the peak current-voltage relationship or the activation time course of the TTX-sensitive Na+ currents in the neuromuscular synapse of the lobster walking leg and in the rat trigeminal ganglion neurons. Effective at concentrations of 10 nM in cultured rat cortical neurons.
