Ondansetron hydrochloride is a potent and selective 5-HT3A channel blocker. It is used as an anti-emetic drug for patients suffering from the side effects of antineoplastic drugs such as cyclophosphamide and methotrexate and also preventing post chemotherapy nause2. Another modality for which Ondansetron’s anti-emetic characteristics are used is the treatment of post-operative nausea. In this case a recent study shows that although widely used today for this purpose, in the case of failed prophylactic treatment prior to the surgery, the drug is effective in only 30-50% of patients. In one recent case report Ondansetron caused serotonergic toxicity in children characterized by hyperthermia, mental status changes and muscular hypertonicity.
产品描述
A Potent and Selective Blocker of 5-Hydroxytryptamine Receptor 3A
产品形式
Serotonin (5-hydroxytryptamine, 5-HT) is a monoamine neurotransmitter synthesized from the amino acid tryptophan by the enzyme tryptophan-decarboxylase. The 5-HT3 channel is a ligand gated ion channel receptor of the cys-loop channel family. It is a pentamer with five subunits surrounding a central channel.
