NASPM has been shown to block excitatory synaptic potentials evoked by stimulation of parallel fibers in guinea pig cerebellar Purkinje cells. In hippocampus, NASPM has been reported to exert a potent and selective suppression of hippocampal epileptic discharges mediated by non-NMDA receptors. In addition, it has been reported that EPSCs in CA1 neurons of the gerbil hippocampus after ischemia are mediated by Ca2+-permeable non-NMDA receptors, and that these abnormal EPSCs are effectively suppressed by NASPM.
产品描述
An Antagonist of AMPA Receptors
产品形式
1-Naphthyl acetyl spermine (NASPM), a synthetic analogue of Joro spider toxin (JSTX), is selective antagonist of Ca2+-permeable AMPA receptors. It blocks AMPA receptors lacking the GluR2 subunit expressed in rat hippocampal neurons with IC50 values of 0.33 μM.
