Mambalgins define a new structural and functional class among snake three-finger toxins. These type of toxins are found in snake venoms (specifically in black mambas) and are characterized by their distinctive structure. Mambalgins are the only three-finger toxins to target ASIC channels and show no neurotoxic effect. These three-finger toxins show an analgesic effect against acute and inflammatory pain upon central and peripheral injection that can be as strong as morphine. Mambalgins cause much less tolerance than morphine and no respiratory distress.
产品描述
A Blocker of ASIC1a and ASIC1b Channels
产品形式
Acid-sensing ion channels (ASICs) are voltage-independent proton-gated cation channels that are largely expressed in the nervous system as well as in some non-neuronal tissues. In rodents, six different isoforms (ASIC1a, 1b, 2a, 2b, 3 and 4) can associate into homo- or hetero-trimers to form a functional channel.
保存建议
艾美捷为您提供的Alonmone Labs原装进口的Mambalgin-3 (5 x 35 µg)产品可室温运输，建议您在收到产品后将其置于合适的温度下保存。
