Miconazole is a synthetic antifungal derivative of imidazole. It is a blocker of KV11.1 (hERG), KV1.3 and KV1.5 channels and has an effective concentration of 1-100 μM and an IC50 2.1 μM for the hERG channel in HEK 293 cells. Miconazole inhibits hERG peak tail current in a concentration dependent manner (0.4-40 μM) without being frequency dependent and without affecting other channel kinetics. Blocking hERG channel by Miconazole requires channel activation.
