Mexiletine, an orally effective antiarrhythmic drug of the IB class with use-dependent sodium channel-blocking properties, is used for the treatment of ventricular arrhythmia. Also, it is among the few drugs used to reduce or prevent myotonia, to treat long QT-3 syndrome12 and to alleviate neuropathic pain1.
产品描述
An Antiarrhythmic Drug with Use Dependent NaV Channel Blocker Properties
产品形式
The clinical term myotonia is used to identify a series of dominant and recessive forms of genetic skeletal muscle diseases characterized by abnormal membrane excitability and delayed muscle relaxation after voluntary contraction. Sodium channel myotonias, paramyotonia congenita, and hyperkaliemic periodic paralysis are due to mutations of the gene coding for the skeletal muscle type of voltage-gated sodium channels.
