L-Ascorbic acid (ascorbate) is an endogenous redox agent that selectively inhibits native CaV3.2 channels in the peripheral and central neurons.
产品描述
A Blocker of T-type CaV Channels
产品形式
The T-type calcium channel belongs to the voltage-gated Ca2+ channel (CaV) family. "T" stands for transient, referring to the length of activation. As with other sub-types of voltage-gated Ca2+ channels, the α1 subunit is the one that determines most of the channel's properties. T-type calcium channels may contain one of three α1 subunits, α1G (CaV3.1), α1H (CaV3.2) or α1I (CaV3.3) .nT-type Ca2+ channels are involved in the control of neuronal excitability and their gating can be modulated by a variety of redox agents.
