ICA-110381 is a synthetic opener of KV7 channels with an effective concentration of 0.1μM-10μM. In hippocampal CA1 cells, ICA-110381 reduces cell membrane excitability caused by hyperpolarization and decreases membrane resistance. It exhibits strong anticonvulsant properties by acting mainly on the KCNQ2 subunit of the KV7 channel and reduces seizure severity and frequency