Neuronal Nicotinic acetylcholine receptors (nAChRs) are members of the Cys-Loop ligand-gated ion channel superfamily, located both in the peripheral and central nervous systems (PNS and CNS, respectively) and are validated therapeutic targets for various CNS pathologies. They can be divided into two main groups: those that contribute to receptors that are sensitive to the snake toxin α-Bungarotoxin (αBgt) and those that do not bind this toxin. Another important distinction is that the three αBgt-sensitive subunits (α7–9) can reconstitute functional homomeric receptors when expressed in a host system.
产品描述
A Positive Allosteric Modulator of alpha7 nAChR
产品形式
Neuronal Nicotinic acetylcholine receptors (nAChRs) are members of the Cys-Loop ligand-gated ion channel superfamily, located both in the peripheral and central nervous systems (PNS and CNS, respectively) and are validated therapeutic targets for various CNS pathologies. They can be divided into two main groups: those that contribute to receptors that are sensitive to the snake toxin α-Bungarotoxin (αBgt) and those that do not bind this toxin. Another important distinction is that the three αBgt-sensitive subunits (α7–9) can reconstitute functional homomeric receptors when expressed in a host system.
