中文名称

艾芬地尔（+）-酒石酸盐（半酒石酸盐）（25毫克）

英文名字

Ifenprodil (+)-tartrate salt (hemitartrate salt)

供应商

Alomone

产品货号

ALO-I-105-25

产品报价

￥已停产

产品说明书

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购买方式

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产品新闻

背景资料

fenprodil is an atypical, selective, noncompetitive, voltage-independent partial antagonist of N-methyl-D-aspartate (NMDA) receptors. Its maximal inhibition is approximately at 90%. Ifenprodil inhibits GluN2B-containing receptors with high affinity and is more potent for GluN1/GluN2B receptors. Ifenprodil action is pH-dependent and may cause an increase in tonic proton inhibition. There is evidence that ifenprodil binds outside the ion channel pore to the large interlobe cleft of the NR2B N-terminal domain and acts at a discrete sites with an allosteric interaction. Mutations at distinct residues in the R domain of NR1 and NR2B greatly influence ifenprodil inhibition, thus it seems that this region may form part of the ifenprodil binding site. IC50 values of ifenprodil are 0.15 μM for NR2B subunit, 39 μM for NR2A, 29 μM for NR2C and 76 μM for NR2D.

产品描述

An Antagonist of NMDA Receptors

产品形式

fenprodil is an atypical, selective, noncompetitive, voltage-independent partial antagonist of N-methyl-D-aspartate (NMDA) receptors. Its maximal inhibition is approximately at 90%. Ifenprodil inhibits GluN2B-containing receptors with high affinity and is more potent for GluN1/GluN2B receptors. Ifenprodil action is pH-dependent and may cause an increase in tonic proton inhibition. There is evidence that ifenprodil binds outside the ion channel pore to the large interlobe cleft of the NR2B N-terminal domain and acts at a discrete sites with an allosteric interaction. Mutations at distinct residues in the R domain of NR1 and NR2B greatly influence ifenprodil inhibition, thus it seems that this region may form part of the ifenprodil binding site. IC50 values of ifenprodil are 0.15 μM for NR2B subunit, 39 μM for NR2A, 29 μM for NR2C and 76 μM for NR2D.

保存建议

艾美捷为您提供的Alonmone Labs原装进口的Ifenprodil (+)-tartrate salt (hemitartrate salt) (25 mg)产品可室温运输，建议您在收到产品后将其置于合适的温度下保存。

其他

Alomone成立于1989年,已经成为全世界科学家信赖的最全面的离子通道研究工具供应商。产品覆盖离子通道、G蛋白耦联受体和神经信号研究所需的一抗、小分子、蛋白质和多肽等。所有Alomone产品均进行了生物实验验证，以冻干粉形式提供，可确保产品生物活性和保质期。Alomone可提供多种包装规格，灵活方便。作为Alomone Labs在中国的区域总代理，艾美捷科技有限公司将为中国客户提供最全面的Alomone Labs产品以及客户订制化服务。

注意

该页面的中文产品信息的翻译，仅供参考。准确的产品信息请以厂家的英文说明书为准。下单前，请浏览说明书确认。

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