MMK1 is a selective and potent agonist of the Formylpeptide receptor FPR2, which was originally derived from a random peptide library and was identified by a novel autocrine selection method in yeasts engineered to express human FPR2.
产品描述
A Potent and Selective Agonist of FPR2 G-Protein Coupled Receptors
产品形式
Chemotactic factors from both Gram-positive and Gram-negative bacteria are short peptides with N-formyl methionine at the N-terminus (extensively reviewed in reference 1). These peptides are released from bacteria during infection and activate formyl peptide receptor (FPR), a member of G-protein coupled receptors (GPCRs). In human, the FPR family consists mainly of three receptors, FPR1, FPR2/ALX (formerly FPRL1), and FPR3 (formerly FPRL2) which all couple to the Gi subtype of G-proteins and ultimately lead to the activation of phospholipase C and intracellular Ca2+ increase.
