中文名称

2,5-二甲基塞来昔布（10毫克）

英文名字

2,5-dimethylcelecoxib

供应商

Alomone

产品货号

ALO-D-150-10

产品报价

￥已停产

产品说明书

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购买方式

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产品新闻

背景资料

2,5-dimethylcelecoxib, also known as DMC, is a synthetic opener of KV7 channels in smooth muscle cells. It is a derivative of Celecoxib without its COX-2 inhibitory function. In Asthma and other lung diseases, airways become hyperconstricted because of the secretion of various endogenous substances. DMC causes an increase in KV7 currents and restores current amplitudes in guinea pig ASMC (air smooth muscle cells). This effect is also seen after the application of bronchoconstrictors such as Methacholine and Histamine suggesting DMC can regulate and dilate airway diameter in bronchoconstricting diseases. DMC is a potent activator of apoptotic pathways and also suppresses production of prostaglandins in vitro by inhibiting cytokine-triggered upregulation of microsomal PGE-synthase-1. These properties may be valuable in the research of cancer.

产品描述

A KV7 Channel Opener

产品形式

KV7 or KCNQs are voltage-gated potassium channels. These channels are mainly responsible for the cardiac and auditory IKs current and the neuronal M-current but can be found in other tissues as well. Voltage-gated potassium channels are tetramers of α-subunits, which surround a K -selective pore. The different five Kv7 subtypes have distinct assembly preferences encoded by a C-terminal cytoplasmic assembly domain, the A-domain Tail. This domain is a self-assembling, parallel, four-stranded coiled coil.

保存建议

艾美捷为您提供的Alonmone Labs原装进口的2,5-dimethylcelecoxib (10 mg)产品可室温运输，建议您在收到产品后将其置于合适的温度下保存。

其他

Alomone成立于1989年,已经成为全世界科学家信赖的最全面的离子通道研究工具供应商。产品覆盖离子通道、G蛋白耦联受体和神经信号研究所需的一抗、小分子、蛋白质和多肽等。所有Alomone产品均进行了生物实验验证，以冻干粉形式提供，可确保产品生物活性和保质期。Alomone可提供多种包装规格，灵活方便。作为Alomone Labs在中国的区域总代理，艾美捷科技有限公司将为中国客户提供最全面的Alomone Labs产品以及客户订制化服务。

注意

该页面的中文产品信息的翻译，仅供参考。准确的产品信息请以厂家的英文说明书为准。下单前，请浏览说明书确认。

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