7-chlorokynurenic acid (7-CKA), a derivative of kynurenic acid, is a potent and selective antagonist of the N-methyl-D-aspartate (NMDA) receptor. 7-CKA acts and binds with high affinity to the glycine binding site located on the NMDA receptor. This compound has neuroprotective, antinociceptive and anticonvulsive effects lacking the ability to penetrate the blood brain barrier and has therapeutic potential in some types of epilepsy1-3. Several studies that conducted radioligand binding experiments showed that 7-chlorokynurenic acid binds to the strychnine- glycine binding site with high affinity with an IC50 value of 0.56 μM
