Candesartan (Atacand, Parapres, Kenzen) is a synthetic antagonist of the Angiotensin II type 1 and 2 receptors. It has an effective concentration of 1-100 nM and an IC50 15 μg/kg. Candesartan is used for the treatment of essential hypertension and congestive heart failure with reduced ejection fraction under 40%. Moreover, Candesartan was found to be effective combined with hydrochlorodiazide for the treatment of severe hypertension. It is administered orally as a pro-drug which is activated by ester hydrolysis during absorption from the gut and has a low bioavailability of 15%. Candesartan has a higher affinity for the AT1 receptor than other drugs of its type such as irbesartan, valsartan and losartan and also dissociates slower from the receptor enabling a longer half-life period of 9 hours. It is mainly secreted unchanged in the feces and stool but undergoes some metabolism by CYP 2C9
产品描述
An Antagonist of Angiotensin II Receptor Type-1 and Angiotensin II Receptor Type-2
