ASIC channels sense protons and interact with proteins (namely proteases) and other ions such as Zn2+ and Ca2+ through their extracellular domains. The extracellular loop of ASIC1a undergoes cleavage by extracellular trypsin (a serine protease) which is responsible for shifting the pH dependence of the channel activation and inactivation to more acidic pH
应用类型
应用类型：IC、 IH、 LCI、 WB n；预测应用类型：IFC、 IP
免疫原
pan ASIC (胞外)抗体（50 ul）的免疫原肽段为(C)TRYGKELSMVKIPSK。此免疫原序列来源于368 - 382位氨基酸残基，该序列来源于大鼠ASIC1蛋白 (Accession编号为P55926)，胞外环。
