The existence of resting K+ conductance has been known for some time. Only recently has the Nalcn (sodium leak channel non-selective protein) has been found responsible for the resting Na+ conductance.Nalcn is a member of the NaV and CaV channels family which have four homologous repeats of six transmembrane domains. One structural difference is that Nalcn is less positively charged in the voltage sensing segment. The protein forms voltage-independent non-inactivating channel which is permeable to Na+, K+ and Ca2+ ion.nEvidence suggests that Nalcn is a non-redundant and thus essential channel since knock-out mice display disrupted respiratory rhythm and die with 24 hours of birth. In addition, isolated neurons from these mice have decreased excitability.The channel is extensively expressed in the central nervous system1, heart, pituitary and adrenal glands and pancreatic islet cell.In pancreatic islets, Nalcn is activated by acetylcholine via its physical association with M3 muscarinic receptor, and potentiates insulin secretion induced by glucose uptake
应用类型
经验证，该抗体可应用于IC、IH、LCI、WB等实验应用，也可用于IFC、IP等实验。
免疫原
Sodium Leak Channel Non-Selective Protein (Nalcn) (胞外)抗体的免疫原肽段为(C)SMMFESPFRRVMH。此免疫原序列来源于902-914 位氨基酸残基，该序列来源于大鼠Sodium leak channel non-selective protein (Accession编号为Q6Q760)。 胞外, S1-S2 结构域 III。
来源宿主
兔
反应性
反应性：人、 小鼠、 大鼠
保存建议
艾美捷为您提供的Sodium Leak Channel Non-Selective Protein (Nalcn) (胞外)抗体(50 ul)为室温运输，建议您收到产品后﹣20℃保存。
