Shank family proteins (shank1, shank2 and shank3) are neuronal scaffold proteins that organize a cytoskeleton-associated signaling complex at the postsynaptic density (PSD) of nearly all excitatory glutamatergic synapses in the mammalian brain.Shank1 mRNA, being synthesized in dendritic spine, can locally control the spine morphology. The Shank1 gene is located on chromosome 19q13.33 and contains 23 exons and two alternative promoters leading to two distinct isoforms. Shank1 is highly expressed in the cortex and hippocampus.Recent studies indicate that Shank1 is a causative gene for idiopathic autism spectrum disorders (ASD)1. In addition it was found that Shank1 has a role in working memory deficits in schizophrenia6. Shank1 knock-out mice display increased anxiety and decreased vocal communication
应用类型
经验证，该抗体可应用于WB等实验应用，也可用于IC、IH、IP等实验。
免疫原
Shank1抗体的免疫原肽段为(C)RSQEGRQESRSDKAK。此免疫原序列来源于614- 628 位氨基酸残基，该序列来源于大鼠Shank1 (Accession编号为Q9WV48)。胞内, between the SH3和PDZ 结构域s。
