KVβ2 (or KCNAB2) is a member of a family of proteins that regulate the activity of voltage-dependent K+ channels. The other members of the family are KVβ1 and KVβ3.KVβ2, as well as the other KVβ subunits can bind to all the members of the large KV1.x (Shaker) channel subfamily. However, recent evidence suggests that it can also bind to members of the KV4.x subfamily.nKVβ2 is the most abundant β subunit in the brain where it couples with all the Kv1.x subunits, but the protein is also expressed in peripheral tissues including heart, lung and cells of hematopoietic origin such as T cells where it couples with KV1.3, the dominant voltage-dependent K+ channel in these cells.
