The KV11.1 (HERG) channel is a member of the ether-a-go-go (EAG) subfamily of voltage-dependent K+ channels that includes the related proteins KV11.2 and KV11.3 (erg2 and erg3). KV11.1 possess the signature structure of the voltage-dependent K+ channels: six membrane-spanning domains and intracellular N and C termini.nThe KV11.1 current is characterized by strong inward rectification with slow activation and very rapid inactivation kinetics. The channel is expressed in the brain and heart (where it underlies the IKr current) and has a central role in mediating repolarization of action potentials.
应用类型
经验证，该抗体可应用于FC
免疫原
KV11.1 (胞外)-FITC抗体的免疫原肽段为AFLLKETEEGPPATEC 对应于430-445位氨基酸残基，该序列来源于人类KV11。1 (HERG) (Accession编号为Q12809 )。 胞外, between S1和S2 结构域s。
