The RET proto-oncogene on human chromosome 10q11.2, encodes a receptor tyrosine kinase (RTK) activated by members of the glial cell line-derived neurotrophic factor (GDNF) ligand family (GDNF, neurturin, artemin, and persephin) in conjunction with a ligand-specific coreceptor (GFRα1-4). RET belongs to the cadherin superfamily, and it has been suggested that the ret gene is the result of a recombination between a gene encoding a tyrosine kinase receptor and a gene encoding an ancestral cadherin at an early stage of evolution. The extracellular domain of RET comprises, as observed for other tyrosine kinase receptors, a cysteine-rich domain, but also four cadherin-like domains
应用类型
经验证，该抗体可应用于IC、IFC、IH、LCI、WB等实验应用，也可用于 IP等实验。
免疫原
Ret (胞外)抗体的免疫原肽段为CEWRQGDGKGITR。此免疫原序列来源于541-553位氨基酸残基，该序列来源于人类Ret (Accession编号为P07949)。胞外，N端。
