The GDNF family ligands (GFLs) belong to the super family of the TGF-β. They belong to the group of cystine-knot protein and function as homodimers. This family includes glial cell line-derived neurotrophic factor (GDNF), artemin (ARTN), Neurturin (NRTN) and persephin (PSPN).nThese factors are heavily involved in the development and function of the nervous system (both central and peripheral). In particular GDNF has an important role outside the nervous system where it plays a role in kidney morphogenesis.nIn general GFLs all signal through a signal through the receptor tyrosine kinase Ret. Their specificity is implemented by different GDNF family receptor a (GFRα), which act as co-receptors. These extracellular proteins are bound to the plasma membrane via a glycosyl phosphatidyl inositol (GPI) anchor. GFRα1-4 are responsible for the binding of GDNF, NRTN, ARTN, and PSPN respectively and the subsequent activation of Ret. Soluble forms of the receptor by the cleavage of a yet unknown phospholipase or protease can be detected1,3. Also alternative spliced forms of the protein can lead to soluble forms of GFRα receptors
应用类型
经验证，该抗体可应用于IC、IH、LCI、WB等实验应用，也可用于IFC、IP等实验。
免疫原
GDNF Family 受体 Alpha4 (胞外)抗体的免疫原肽段为(C)GSRDG(S)PEEGGPR。此免疫原序列来源于160-172 位氨基酸残基，该序列来源于大鼠GFRα4 (Accession编号为Q9EPI2)。胞外，N端。
来源宿主
兔
反应性
反应性：小鼠、 大鼠
保存建议
艾美捷为您提供的GDNF Family 受体 Alpha4 (胞外)抗体(50 ul)为室温运输，建议您收到产品后﹣20℃保存。
