In general GFLs all signal through a signal through the receptor tyrosine kinase Ret. Their specificity is implemented by different GDNF family receptor a (GFRα), which act as co-receptors. These extracellular proteins are bound to the plasma membrane via a glycosyl phosphatidyl inositol (GPI) anchor. GFRα1-4 are responsible for the binding of GDNF, NRTN, ARTN, and PSPN respectively and the subsequent activation of Ret. Soluble forms of the receptor by the cleavage of a yet unknown phospholipase or protease can be detected. Also alternative spliced forms of the protein can lead to soluble forms of GFRα receptors.In respect to their important role in development, individual knockout of either gdnf, gfra1 or ret gives rise to lethal phenotypes
应用类型
经验证，该抗体可应用于IC、IH、LCI、WB等实验应用，也可用于IFC、IP等实验。
免疫原
GDNF Family 受体 Alpha1 (胞外)抗体的免疫原肽段为CRSAMEALKQKS。此免疫原序列来源于72-83 位氨基酸残基，该序列来源于大鼠GFRα1 (Accession编号为Q62997)。 胞外 结构域。
来源宿主
兔
反应性
反应性：人、 小鼠、 大鼠
保存建议
艾美捷为您提供的GDNF Family 受体 Alpha1 (胞外)抗体(50 ul)为室温运输，建议您收到产品后﹣20℃保存。
