The p75NTR receptor is a member of the TNF receptor superfamily. p75NTR, like all the superfamily members is a type I transmembrane protein with tandem cysteine-rich domains in the extracellular portion and a intracellular death domain. p75NTR binds its ligands as a homodimer but can also form heterodimers with other receptors such as TrkA, TrkB, TrkC, Nogo receptor and sortilin. The precise multimeric receptor complex formed between p75NTR and the other receptors will determine the ligand being recognized (see below) and the biological response to its binding.
应用类型
经验证，该抗体可应用于FC
免疫原
Human p75NTR (ext.)-FITC抗体的免疫原肽段为CEEIPGRWITRSTPPE。此免疫原序列来源于188-203位氨基酸残基，该序列来源于人类p75NTR (SwissProt Accession编号为P08138)。 胞外, stalk 结构域
