Recently, several key players of the store operated complex have been identified. Orai1 (also known as CRACM1) acts as the store operated Ca2+ channel (SOC) and STIM1, which acts as the endoplasmic reticulum Ca2+ sensor. The formation of functional channels by Orai1 requires the presence of both Orai1 and STIM1 proteins working as a complex that involves the co-clustering of Orai1 on the plasma membrane with STIM1 on the endoplasmic reticulum. TRPC1, a member of the transient receptor potential family was also suggested to act as a player in the SOC complex7. In T-cells, Ca2+ entry following activation by antigen-receptor engagement occurs solely through CRAC channels where Orai1 constitutes the pore forming subunit.nOrai1 is a plasma membrane protein with four potential transmembrane domains and intracellular N- and C-termini. In addition, two mammalian homologs to Orai1 have been identified; Orai2 and Orai3. All three, Orai1 Orai2 and Orai3, are capable of forming store operated channels with different properties
应用类型
经验证，该抗体可应用于IC、IFC、LCI、 WB等实验应用，也可用于IH等实验。
免疫原
Human Orai1 (胞外)抗体的免疫原肽段为合成 mapping to an 胞外 sequence位氨基酸残基，该序列来源于人类Orai1 (Accession编号为Q96D31)
