H4 Histamine Receptor couples to Gi/G0 proteins and receptor activation leads to inhibition of adenylate cyclase, mobilisation of calcium from intracellular stores and activation of the mitogen-activated protein kinase (MAPK) cascade. nH4 Histamine Receptor is largely expressed in haemopoietic cells including mast cells, eosinophils, dendritic cells and T lymphocytes. H4 Histamine Receptors modulate eosinophil migration and the selective recruitment of mast cells leading to amplification of histamine-mediated immune responses. In addition, H4 Histamine Receptors are involved in dendritic cell activation and the regulation of T lymphocyte cytokine production.nThese studies indicate that H4 Histamine Receptor is an attractive therapeutic target for the treatment of inflammatory disorders, such as allergy, asthma, chronic pruritus and autoimmune diseases.
应用类型
经验证，该抗体可应用于IFC、WB等实验。
免疫原
Human H4 Histamine 受体 (胞外)抗体的免疫原肽段为HTLFEWDFGKEIC。此免疫原序列来源于75-87位氨基酸残基，该序列来源于人类H4 Histamine 受体 (Accession编号为Q9H3N8)，第二胞外环。
