- 中文名称
HVCN1抗体（50 ul）
- 英文名字
- Anti-HVCN1
- 供应商
- Alomone
- 产品货号
- ALO-AHC-001-50
- 产品报价
- ￥已停产
- 产品说明书
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- 购买方式
- 银行转账、电汇、支票、现金，在线支付宝及网银支付，或直接与我们电话联系400-6800-868。
- 产品新闻
- 背景资料
- The fundamental role of HVCN1 is to pump out protons, thereby increasing the intracellular pH. The channel is exclusively selective for H+ and opens upon membrane depolarization, although its open state hugely depends on the pH on both sides of the membrane4. Its role is best described in leukocytes where phosphorylation via PKC on a Thr residue potentiates the activity of the channel and increases its open state, thereby increasing the H+ current across the membrane, in this manner mediating optimal NADPH-oxidase (whose optimal activity is at pH 7.5) required for the production of reactive oxygen species (ROS) necessary for phagocytosis to occur.nApart from leukocytes, HVCN1 is also expressed in basophils where its activation mediates histamine release. In B cells, it maintains optimal signaling, such that ROS production is maintained high10. HVCN1 was found to regulate human spermatozoa activation. Finally, in the airway mucosa, where it regulates pH, channel gating there, is mostly mediated by differences in pH across the membrane as opposed to the membrane potential.
- 应用类型
- 经验证，该抗体可应用于IFC、WB等实验应用，也可用于 IC、IH、IP等实验。
- 免疫原
- HVCN1抗体的免疫原肽段为(C)GDDYHTWNVNYKK。此免疫原序列来源于32-44 位氨基酸残基，该序列来源于小鼠 HVCN1 (Accession编号为Q3U2S8)。胞内, N端
- 来源宿主
- 兔
- 反应性
- 反应性：人、 小鼠、 大鼠
- 保存建议
- 艾美捷为您提供的HVCN1抗体(50 ul)为室温运输，建议您收到产品后﹣20℃保存。
- 其他
- Alomone成立于1989年,已经成为全世界科学家信赖的最全面的离子通道研究工具供应商。产品覆盖离子通道、G蛋白耦联受体和神经信号研究所需的一抗、小分子、蛋白质和多肽等。所有Alomone产品均进行了生物实验验证，以冻干粉形式提供，可确保产品生物活性和保质期。Alomone可提供多种包装规格，灵活方便。作为Alomone Labs在中国的区域总代理，艾美捷科技有限公司将为中国客户提供最全面的Alomone Labs产品以及客户订制化服务。
- 注意
-
该页面的中文产品信息的翻译，仅供参考。准确的产品信息请以厂家的英文说明书为准。下单前，请浏览说明书确认。
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