甘氨酸受体β抗体（50 ul）-Anti-Glycine Receptor Beta代理/参数/厂家-一抗-艾美捷科技有限公司

PRODUCT CENTER

一抗

产品中心

当前位置：首页 > 产品中心 > 免疫学产品 > 一抗

背景资料: The amino acid glycine mediates neuronal inhibition by activating glycine receptors (GlyRs), which are ligand-gated chloride channels of the nicotinic acetylcholine receptor superfamily. GlyRs are known to mediate postsynaptic inhibition in spinal cord, brain stem and some higher brain regions1. GlyRs are members of the pentameric Cys-loop family of ionotropic neurotransmitter receptors. GlyRs are composed are composed of homologous α (α1-α4) and β subunits. Upon synthesis at the endoplasmic reticulum (ER), all GlyRα subunits can assemble into functional homopentamers that are inserted into the plasma membrane. In contrast, the GlyRβ subunit requires stoichiometric coassembly with GlyRα subunits for ER exit and cell surface expression. Each subunit consists of an extended N-terminal extracellular domain, four transmembrane domains, and a large intracellular loop between transmembrane domains 3 and 4. The β subunit is responsible for synaptic localization of the GlyRs by interacting with the postsynaptic scaffolding protein gephyrin. GlyRβ subunit is reported to interact with the proteins Vacuolar Protein Sorting 35 (Vps35) and Neurobeachin (Nbea).nGlyRβ mRNA is abundantly found throughout the late embryonic and postnatal brain.Mutations in GLRB, the gene encoding GlyRβ, have been discovered in patients with hyperekplexia, in the mouse mutant spastic and the zebrafish bandoneon mutant.

免疫原: Glycine 受体 Beta抗体的免疫原肽段为HISTLQVGETRC。此免疫原序列来源于394-405 位氨基酸残基，该序列来源于大鼠Glycine 受体 β (Accession编号为P20781)。第二胞内环。

其他: Alomone成立于1989年,已经成为全世界科学家信赖的最全面的离子通道研究工具供应商。产品覆盖离子通道、G蛋白耦联受体和神经信号研究所需的一抗、小分子、蛋白质和多肽等。所有Alomone产品均进行了生物实验验证，以冻干粉形式提供，可确保产品生物活性和保质期。Alomone可提供多种包装规格，灵活方便。作为Alomone Labs在中国的区域总代理，艾美捷科技有限公司将为中国客户提供最全面的Alomone Labs产品以及客户订制化服务。