Neuronal calcium-binding proteins (CaBP1-8) belong to a subclass of the calmodulin (CaM) superfamily and regulate in particular Ca2+ channel targets in the brain and retina.nCaBP4 contains two globular domains (N- and C-lobe) that each contains a pair of EF- hand motifs connected by a central linker. The second EF-hand in CaBP4 lacks conserved residues in the binding loop and is predicted to not bind Ca2+. CaBP4 interacts structurally with the C-terminal region of CaV1.4 and this Ca2+-dependent interaction has been implicated in the modulation of voltage-dependent CaV1.4 activation.nMultiple isoforms of CaBPs are localized in different neuronal cell types and perform specialized roles in signal transduction. The CaBP4 isoform regulates voltage-gated Ca2+ channels in retinal photoreceptor cells. In the eye, CaBP4 is localized at the photoreceptor synaptic terminals in rods and cones3. CaBP4 is essential for the development and maintenance of the photoreceptor synapse, likely through functional modulation of the photoreceptor Ca2+ channels, α1F L-type voltage- dependent calcium channels (CaV1.4), and neurotransmitter release.nMutations in both CaV1.4 and CaBP4 have been identified in patients suffering from congenital stationary night blindness type 2 (CSNB2), indicating that defects in Ca2+-dependent regulation of CaV1.4 by CaBP4 are closely associated with CSNB2. Indeed, deletion of CaBP4 in the mouse leads to a CSNB2-like phenotype.
应用类型
经验证，该抗体可应用于WB等实验应用，也可用于IC、IH、IP等实验。
免疫原
Calcium-Binding Protein 4抗体的免疫原肽段为(C)RTYGPLLNRMFGKDR。此免疫原序列来源于105-120 位氨基酸残基，该序列来源于小鼠 Calcium-Binding Protein 4 (Accession编号为Q8VHC5)。胞内。
来源宿主
兔
反应性
反应性：小鼠、 大鼠、也可反应于： 人
保存建议
艾美捷为您提供的Calcium-Binding Protein 4抗体(25 ul)为室温运输，建议您收到产品后﹣20℃保存。
