Gap junctions are usually found in clusters and enable intercellular communication by allowing the passage of small molecules between cells3. They play important roles in different biological processes. These include differentiation, cell cycle synchronization, cellular development, neuronal activity and the immune response.nDue to their important roles, mutations in connexins are linked with a number of diseases such as neurodegenerative disorders, skin diseases and developmental abnormalities. A mutation in the gene encoding Connexin-32 is associated with and is the cause for Charcot–Marie–Tooth disease (CMT), a form of demyelinating disease characterized by muscular weakness, affecting more males than females.
