- 中文名称
两孔钙通道蛋白2（胞外）抗体（50 ul）
- 英文名字
- Anti-Two Pore Calcium Channel Protein 2 （extracellular)
- 供应商
- Alomone
- 产品货号
- ALO-ACC-072-50
- 产品报价
- ￥已停产
- 产品说明书
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- 购买方式
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- 产品新闻
- 背景资料
- Among various vertebrate species, three genes are known to encode two-pore segment channels (TPCs) termed TPC1-3. Interestingly TPC3 seems to be absent from the genomes of primates and rodents. The primary sequence of these channels indicates the presence of two putative pore-forming repeats. Each repeat contains six transmembrane domains and a pore loop, a structure strikingly reminiscent of many voltage-gated Na+ (Nav) and Ca2+ (Cav) channels. These twelve transmembrane structures are further thought to form functional dimers3. Both TPC1 and TPC2 show ubiquitous expression, while that of TPC1 is exceptionally high in spleen, lung, liver, and kidney.Ca2+-mobilizing messengers such as inositol triphosphate, cyclic ADP ribose and nicotinic acid adenosine dinucleotide phosphate (NAADP) are responsible for the intracellular changes in Ca2+ ion concentration.n In contrast to the other Ca2+-mobilizing agents, NAADP, the most potent of these Ca2+ releasing molecules increases the cytosolic Ca2+ concentration via Ca2+ channels located on acidic vesicles (endolysosomes). Only quite recently, after almost a decade of being cloned, TPC1 and TPC2 were both found to be responsible for the NAADP-induced release of Ca2+ . Evidence that these two channels are indeed responsible for the release of Ca2+ is quite compelling since overexpression of TPC1 and its knockdown or point mutation of a critical residue increase and exacerbate Ca2+ release respectively. In addition, b-cells from TPC2 knockout mice exhibited no Ca2+ release from endolysosomes upon NAADP stimulation8. Finally, in a study using immunopurified channels, it was demonstrated that TPC1 and TPC2 both respond to very low concentrations of NAADP and are unequivocally responsible for the release of Ca2+, whereas TPC3 may negatively regulate the release of Ca2+. As these channels have only recently been discovered, very little is known about their physiology and gating mechanisms. Their probable involvement in a number of diseases such as lysosomal storage disease (LSDs), caused by the dysfunction of lysosomal associated proteins, has yet to be deciphered.
- 应用类型
- 经验证，该抗体可应用于IC、IH、LCI、WB等实验应用等实验应用，也可用于IFC、IP等实验。
- 免疫原
- Two Pore Calcium Channel Protein 2 (胞外)抗体的免疫原肽段为KKTLKSIRW(S)LPE(C) 。此免疫原序列来源于187-199 位氨基酸残基，该序列来源于小鼠 Two pore calcium channel protein 2 ，替代 amino acid 192 with serine (S) (Accession编号为Q8BWC0)第二胞外环。for Two pore calcium channel protein 2 expressed on the plasma membrane。 Luminal for Two pore calcium channel protein 2 expressed on 胞内organelles
- 来源宿主
- 兔
- 反应性
- 反应性：人、 小鼠、 大鼠
- 保存建议
- 艾美捷为您提供的Two Pore Calcium Channel Protein 2 (胞外)抗体(50 ul)为室温运输，建议您收到产品后﹣20℃保存。
- 其他
- Alomone成立于1989年,已经成为全世界科学家信赖的最全面的离子通道研究工具供应商。产品覆盖离子通道、G蛋白耦联受体和神经信号研究所需的一抗、小分子、蛋白质和多肽等。所有Alomone产品均进行了生物实验验证，以冻干粉形式提供，可确保产品生物活性和保质期。Alomone可提供多种包装规格，灵活方便。作为Alomone Labs在中国的区域总代理，艾美捷科技有限公司将为中国客户提供最全面的Alomone Labs产品以及客户订制化服务。
- 注意
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该页面的中文产品信息的翻译，仅供参考。准确的产品信息请以厂家的英文说明书为准。下单前，请浏览说明书确认。
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