- 中文名称
SOCE相关调节因子抗体（25 ul）
- 英文名字
- Anti-SOCE-Associated Regulatory Factor
- 供应商
- Alomone
- 产品货号
- ALO-ACC-067-25
- 产品报价
- ￥已停产
- 产品说明书
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- 购买方式
- 银行转账、电汇、支票、现金，在线支付宝及网银支付，或直接与我们电话联系400-6800-868。
- 产品新闻
- 背景资料
- SOCE-associated regulatory factor (SARAF) is a regulatory protein of cellular Ca2+ homeostasis, encoded by the TMEM66 gene. SARAF is an ER resident protein, which responds to cytosolic Ca2+ elevation after ER Ca2+ refilling.n SARAF is highly conserved in vertebrates, and in mammals it is ubiquitously expressed with high transcript levels in the immune and neuronal tissues. SARAF structure contains validated signal peptide and a putative single membrane spanning domain, a serine-proline rich domain and arginine rich regions followed by a cluster of basic residues at its C-terminal tail.Store-operated Ca2+ entry (SOCE) is an important Ca2+ influx pathway across plasma membrane in many non-excitable cells. In this pathway, intracellular Ca2+ release through IP3 receptor stimulated by a variety of agonists, results in reduction of Ca2+ concentration in the lumen of endoplasmic or sarcoplasmic reticulum. SARAF negatively regulates store operated calcium entry into cells and protects cells from calcium overfilling.STIM, Ca2+ sensor, and Orai, the channel pore forming subunit proteins have been identified as the essential components enabling the reconstitution of Ca2+ release-activated Ca2+ channels that mediate SOCE. Knock-out of Orai1 or STIM1 in mice and mutations evoke SOCE in lymphocytes and other cells.Several findings show that dysregulation of Ca2+ homeostasis is associated with a plethora of pathological conditions including neurodegenerative diseases, skeletal, muscular and cardiovascular disorders. Inherited defects in SOCE due to mutations in genes of the Ca2+ release-activated Ca2+ (CRAC) channel complex causes patients to suffer from a severe form of immunodeficiency that is due to defects in the function of T cells, NK cells and potentially other immune cells.
- 应用类型
- 经验证，该抗体可应用于WB等实验应用，也可用于 IC、IFC、IH、IP等实验。
- 免疫原
- SOCE-Associated Regulatory Factor抗体的免疫原肽段为(C)ELGLSKLKESGKHQS。此免疫原序列来源于141-155 位氨基酸残基，该序列来源于大鼠SOCE-associated regulatory factor (Accession编号为Q6AYN2)。胞内, lumen。
- 来源宿主
- 兔
- 反应性
- 反应性：人、 小鼠、 大鼠
- 保存建议
- 艾美捷为您提供的SOCE-Associated Regulatory Factor抗体(25 ul)为室温运输，建议您收到产品后﹣20℃保存。
- 其他
- Alomone成立于1989年,已经成为全世界科学家信赖的最全面的离子通道研究工具供应商。产品覆盖离子通道、G蛋白耦联受体和神经信号研究所需的一抗、小分子、蛋白质和多肽等。所有Alomone产品均进行了生物实验验证，以冻干粉形式提供，可确保产品生物活性和保质期。Alomone可提供多种包装规格，灵活方便。作为Alomone Labs在中国的区域总代理，艾美捷科技有限公司将为中国客户提供最全面的Alomone Labs产品以及客户订制化服务。
- 注意
-
该页面的中文产品信息的翻译，仅供参考。准确的产品信息请以厂家的英文说明书为准。下单前，请浏览说明书确认。
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