人Orai1（胞外）-FITC抗体（50 ul）-Anti-Human Orai1 （extracellular)-FITC代理/参数/厂家-一抗-艾美捷科技有限公司

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背景资料: Cytosolic calcium (Ca2+) has long been known to act as a key second messenger in many intracellular pathways including synaptic transmission, muscle contraction, hormonal secretion, cell growth and proliferation. The mechanism controlling intracellular Ca2+ level influx either by the calcium-release-activated Ca2+ channels (CRAC), or from intracellular stores, has become of great interest.Recently, several key players of the store operated complex have been identified.3 Orai1 (also known as CRACM1) acts as the store operated calcium channel (SOC) and STIM1, which acts as the endoplasmic reticulum Ca2+ sensor. The formation of functional channels by Orai1 requires the presence of both Orai1 and STIM1 proteins working as a complex that involves the co-clustering of Orai1 on the plasma membrane with STIM1 on the endoplasmic reticulum.TRPC1, a member of the transient receptor potential family was also suggested to act as a player in the SOC complex.In T-cells, Ca2+ entry following activation by antigen-receptor engagement occurs solely through CRAC channels where Orai1constitutes the pore forming subunit.Orai1 is a plasma membrane protein with four potential transmembrane domains and intracellular N- and C-terminus. In addition, two mammalian homologs to Orai1 have been identified; Orai2 and Orai3.All three, Orai1 Orai2 and Orai3, are capable of forming store operated channels with different magnitudes.

免疫原: Human Orai1 (胞外)-FITC抗体的免疫原肽段为(C)KKQPGQPRPTSK。此免疫原序列来源于203-214位氨基酸残基，该序列来源于人类Orai1 (Accession编号为Q96D31)第二胞外环。

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