- 中文名称
CaV3.2抗体（25 ul）
- 英文名字
- Anti-CaV3.2
- 供应商
- Alomone
- 产品货号
- ALO-ACC-025-25
- 产品报价
- ￥已停产
- 产品说明书
- 点击查看
- 购买方式
- 银行转账、电汇、支票、现金，在线支付宝及网银支付，或直接与我们电话联系400-6800-868。
- 产品新闻
- 背景资料
- T-type Ca2+ channels play an important role in many cellular processes such as hormone secretion, neurotransmitter release and cell differentiation. T-type channels are also known to participate in the pacemaker activities of heart and neurons including thalamic neurons.Three genes encoding T-type Ca2+ channels have been cloned and designated as Cav3.2 (α1H), Cav3.1 (α1G) and Cav3.3 (α1I).The Cav3.2 (α1H) channel is widely expressed in various tissues, brain, heart, liver and testis.Involvement of Cav3.2 Ca2+ channels in several pathologies has been described. Overexpression of the Cav3.2 channel was described in prostate cancer cells that are associated with more aggressiveness, invasiveness and poor prognosis.Several point mutations discovered in the Cav3.2 channel that affect gating of the channel were found to be associated with Childhood Absence Epilepsy.One year old mice, deficient in Cav3.2 channel, exhibited severe cardiac pathology, fibrosis, necrosis, lymphocyte infiltration and abnormal coronary function compared to wild-type mice.Recently, it has been demonstrated that T-type channels are expressed in DRG neurons and that small and medium-diameter primary afferent neurons in the dorsal horn expresses almost exclusively the Cav3.2 Ca2+channels. This might indicate a possible role for Cav3.2 in nociception.
- 应用类型
- 经验证，该抗体可应用于IC、IH、IP、WB等实验。
- 免疫原
- CaV3.2抗体的免疫原肽段为CHVEGPQERARVAHS。此免疫原序列来源于581-595 位氨基酸残基，该序列来源于大鼠 Cav3。2 (Accession编号为Q9EQ60 )。胞内环位于结构域 D1和D2。
- 来源宿主
- 兔
- 反应性
- 反应性：人、 小鼠、 大鼠
- 保存建议
- 艾美捷为您提供的CaV3.2抗体(25 ul)为室温运输，建议您收到产品后﹣20℃保存。
- 其他
- Alomone成立于1989年,已经成为全世界科学家信赖的最全面的离子通道研究工具供应商。产品覆盖离子通道、G蛋白耦联受体和神经信号研究所需的一抗、小分子、蛋白质和多肽等。所有Alomone产品均进行了生物实验验证，以冻干粉形式提供，可确保产品生物活性和保质期。Alomone可提供多种包装规格，灵活方便。作为Alomone Labs在中国的区域总代理，艾美捷科技有限公司将为中国客户提供最全面的Alomone Labs产品以及客户订制化服务。
- 注意
-
该页面的中文产品信息的翻译，仅供参考。准确的产品信息请以厂家的英文说明书为准。下单前，请浏览说明书确认。
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