All L-type calcium channels are encoded by one of the CaV1 channel genes. These channels play a major role as a Ca2+ entry pathway in skeletal cardiac and smooth muscles as well as in neurons, endocrine cells and possibly in non-excitable cells such as hematopoetic and epithelial cells. All CaV1 channels are influenced by dihydropyridines (DHP) and are also referred to as DHP receptor. While the CaV1.1 and CaV1.4 isoforms are expressed in restricted tissues (skeletal muscle and retina, respectively), the expression of CaV1.2 is ubiquitous and CaV1.3 channels are found in heart, brain and pancreas. Several peptidyl toxins are described that are specific L-type channels blockers, but so far no selective blocker for one of the CaV1 isoforms have been described.
应用类型
经验证，该抗体可应用于IC、WB等实验。
免疫原
human CaV1.2抗体的免疫原肽段为VNENTRMYIPEENHQ(C)。此免疫原序列来源于2-15位氨基酸残基，该序列来源于人类Cav1。2 (exon 1B) (Accession编号为Q13936)。胞内, N端
