Angiotensin II receptor type 1 or AT1 receptor is one of the receptors that binds the octapeptide hormone Angiotensin II (Ang II).Ang II is the peptide hormone that generates most of the known effects of the renin-angiotensin system (RAS). Ang II is generated from the angiotensinogen protein by the actions of renin, angiotensin converting enzyme (ACE) and other peptidases. Ang II has a central role in cardiovascular homeostasis by regulating vasoconstriction, renal Na+ and water readsorption. In addition, Ang II induces cell growth and proliferation and has pro-inflammatory effects.Most of the physiological actions of Ang II are mediated by AT1 receptor a member of the 7-transmembrane domain, G protein-coupled receptor (GPCR) superfamily.
应用类型
经验证，该抗体可应用于IC、IFC、IH、LCI、WB等实验应用，也可用于 IP等实验。
免疫原
Angiotensin II 受体 Type-1 (胞外)抗体的免疫原肽段为NSSTEDGIKRIQDDC。此免疫原序列来源于4-18位氨基酸残基，该序列来源于人类AT1 受体 (Accession编号为P30556)，胞外, N端
来源宿主
兔
反应性
反应性：人、 小鼠、 大鼠
保存建议
艾美捷为您提供的Angiotensin II 受体 Type-1 (胞外)抗体(25 ul)为室温运输，建议您收到产品后﹣20℃保存。
