RGS21 (Regulator Of G Protein Signaling 21) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and G-AlphaQ Signaling. Regulator of G protein signaling (RGS) proteins are regulatory and structural components of G protein-coupled receptor complexes. RGS proteins are GTPase-activating proteins for Gi and Gq class G-alpha proteins. They accelerate transit through the cycle of GTP binding and hydrolysis and thereby accelerate signaling kinetics and termination.