The protein encoded by RECQL4 is a DNA helicase that belongs to the RecQ helicase family. DNA helicases unwind double-stranded DNA into single-stranded DNAs and may modulate chromosome segregation. RECQL4 is predominantly expressed in thymus and testis. Mutations in RECQL4 are associated with Rothmund-Thomson, RAPADILINO and Baller-Gerold syndromes.