PHC3 (Polyhomeotic Homolog 3) is a Protein Coding gene. Among its related pathways are Cellular Senescence (REACTOME) and SUMOylation. Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A Lys-119, rendering chromatin heritably changed in its expressibility.
