PDCD1LG2 (Programmed Cell Death 1 Ligand 2) is a Protein Coding gene. Diseases associated with PDCD1LG2 include Cysticercosis and Myasthenic Syndrome, Congenital, 14, With Tubular Aggregates. Among its related pathways are T Cell Co-Signaling Pathway: Ligand-Receptor Interactions and Translocation of ZAP-70 to Immunological synapse. An important paralog of this gene is CD274. Involved in the costimulatory signal, essential for T-cell proliferation and IFNG production in a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production (By similarity).
