CDK12 (Cyclin Dependent Kinase 12) is a Protein Coding gene. Among its related pathways are DNA Damage and Formation of HIV elongation complex in the absence of HIV Tat. Cyclin-dependent kinase that phosphorylates the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting as a key regulator of transcription elongation. Regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability. Preferentially phosphorylates Ser-5 in CTD repeats that are already phosphorylated at Ser-7, but can also phosphorylate Ser-2. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leading to affect the response to estrogen inhibitors.
