nGEF . RCC1 is dynamically chromatin-bound throughout the cell cycle, and this localization is required for mitosis to proceed normally . Appropriate association of RCC1 with chromatin is regulated through amino-terminal phosphorylation and methylation . RCC1 regulation of RanGTP levels in response to histone modifications regulates nuclear import during apoptosis . In mitosis RCC1 is phosphorylated at Ser11, possibly by cyclinB/cdc2 . This phosphorylation may play a role in RCC1 interaction with chromatin and its RanGEF activity.蛋白别名为：RCC1 CHC1;基因ID为：1104；蛋白质ID:P18754
