The protein encoded by MAP3K1 （mitogen-activated protein kinase kinase kinase 1）is a serine/threonine kinase and is part of some signal transduction cascades, including the ERK and JNK kinase pathways as well as the NF-kappa-B pathway. The encoded protein is activated by autophosphorylation and requires magnesium as a cofactor in phosphorylating other proteins. This protein has E3 ligase activity conferred by a plant homeodomain (PHD) in its N-terminus and phospho-kinase activity conferred by a kinase domain in its C-terminus.蛋白别名为：mitogen-activated protein kinase kinase kinase 1;基因ID为：4214；蛋白质ID:Q13233
