BCL2L12 (BCL2 like 12)encodes a member of a family of proteins containing a Bcl-2 homology domain 2 (BH2). The encoded protein is an anti-apoptotic factor that acts as an inhibitor of caspases 3 and 7 in the cytoplasm. In the nucleus, it binds to the p53 tumor suppressor protein, preventing its association with target genes. Overexpression of BCL2L12 has been detected in a number of different cancers. There is a pseudogene for BCL2L12 on chromosome 3. Alternative splicing results in multiple transcript variants.蛋白别名为:BCL2L12; BPR; Bcl-2-like protein 12; Bcl2-L-12; Bcl-2-related proline-rich protein;基因ID为:83596;蛋白质ID:Q9HB09
应用类型
WB,ELISA补充:最优的抗体稀释比例需要基于客户实验进行优化.建议的起始稀释比例如下: WB: 1:500-1:2000, ELISA: 1:5000. Not yet tested in other applications.
免疫原
合成多肽:the Internal region of human BCL2L12. at AA rangle: 60-140